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Para saintis Jepun telah menemui SPD ini sebagai agen aktif yang mencetus apoptosis (mematikan sel abnormal/kanser) sejak tahun 1985. Kali ini, para saintis UKM, UTM, UPM, USM, dan FRIM telah memajukan lagi kajian dan menganalisis agen SPD ini terhadap pelbagai jenis kuman kanser. Mereka mendapati SPD berjaya mendormankan antara 85- 100% pertumbuhan sel kanser dan menghalang merebak sel-sel kanser baru. Daripada 5 jenis kuman kanser yang diuji, hanya 1 jenis sahaja yang didormankan 45%, yang lain (4 jenis lagi) berjaya didormankan 85% ke 100%!!!. subhana-Allah.

Oleh itu, dicadangkan kepada pesakit supaya berterusan mengambil SPD ini walaupun mereka telah sihat. Ini kerana jika ditinggalkan pengambilan SPD ini, kemungkinan kuman kanser akan aktif semula.

Wakil: Kamaruddin 019-9918318

Styrylpyrone Derivative (SPD) induces apoptosis in a caspase-7-dependent manner in the human breast cancer cell line MCF-7.

Abstract
Background: Styrylpyrone derivative (SPD) is a plant-derived pharmacologically extracted from Goniothalamus sp. Previously, we have reported that SPD inhibited of MCF-7 human breast cancer cells by inducing apoptotic cell death, while on non-malignant cells. Here, we attempt to further elucidate the mode
Results: We found that the intrinsic apoptotic pathway was invoked, with cytosolic cytochrome c and processing of the initiator caspase-9. Cleaved 8 were not detected. Next, the executioner caspase-7 was leaved and SPD treatment. To confirm that apoptosis was induced following caspase-inhibitor c-DEVD-CHO as used. Pre-incubation of cells with this inhibitor levels and caspase-7 activity in SPD-treated cells to untreated levels.
Conclusions: Taken together, these results suggest SPD as a potent antiproliferative MCF-7 cells by inducing apoptosis in a caspase-7-dependent manner.

(Prof. Dr. Azimahtol H, Alvin & Anna T)

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